Ghrelin Effect on Beta Cell Function in Health and Disease
Status unconfirmed · Not applicable
Conditions studied: Diabetes
In brief
To determine the role of nutrient status on ghrelin regulation of insulin secretion. We hypothesize that ghrelin and glucagon-like peptide-1 (GLP-1)(both are hormones made in the gut,) have differential effects on β-cell function in the fed state. We will compare insulin secretion and glucose turnover during meal ingestion using a dual glucose tracer and mixed meal protocol in subjects receiving ghrelin or saline. We will also determine the role of ghrelin-stimulated GLP-1 levels in this process using the GLP-1 receptor (GLP-1R) antagonist Exendin(9-39) (Ex-9).
Key facts
- Study ID
- NCT01729299
- Run by
- David Dalessio
- People needed
- 30
- Starts
- 2013-04-01
- Expected to finish
- 2014-04-01
- Last updated by the study team
- 2013-04-04
Who can join
Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy men and women
- Ages between 18 and 45 years
- BMI between 18 and 29 kg/m2
You may not qualify if…
- History or clinical evidence of impaired fasting glucose or diabetes mellitus, myocardial infarction within the past year, history or symptoms of congestive heart failure, uncontrolled hypertension, history or active liver or renal disease (AST or ALT >2x upper limits of normal, calculated glomerular filtration rate [GFR] <60).
- History of pituitary or adrenal disorders or neuroendocrine tumor.
- Anemia defined as hematocrit <33%.
- Use of medications that alter glucose metabolism
- Pregnancy or lactation.
- Abnormal Electrocardiogram (ECG): evidence of ischemia or arrhythmia.
- Women who have a positive pregnancy test at any time during the study period.
Where it is running
- University of Cincinnati — Cincinnati, Ohio, United States (enrolling)
- Cincinnati Children's Hospital and Medical Center — Cincinnati, Ohio, United States (enrolling)
Full record on ClinicalTrials.gov
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