Identifying the Genetic Predictors of Severe Acne Vulgaris and the Outcome of Oral Isotretinoin Treatment

Completed

Conditions studied: Acne Vulgaris, Isotretinoin

In brief

The goal of this study is to enroll 250 participants that have joined the MURDOCK Study Horizon 1.5 (Duke IRB Pro00011196) with a current or prior diagnosis of severe acne AND current or prior treatment with oral isotretinoin. All 250 participants will answer a 5-page questionnaire designed to collect information on the diagnosis of severe acne and response to oral isotretinoin treatment. The aim is to identify genetic predictors of severe acne vulgaris and the outcome of oral isotretinoin treatment.

Key facts

Study ID

NCT01727440

Run by

Duke University

People needed

123

Starts

2011-09-01

Expected to finish

2015-08-01

Last updated by the study team

2017-08-24

Who can join

Age: 12 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosed with severe acne while age > 12 and < 18, and
• Completed at least one course of oral isotretinoin treatment; OR started treatment but discontinued prior to completion due to adverse side effects (with the exception of dry skin - see "exclusion criteria"); OR are currently undergoing and plan to complete treatment

You may not qualify if…

• Patients who are not willing to participate in this study
• Patients who experienced inflammatory bowel disease (IBD) prior to oral isotretinoin treatment
• Patients who did not complete the oral isotretinoin treatment because of pregnancy, dry skin, or reasons other than adverse side effects listed above
• Patients who are not willing to or cannot provide a blood sample for Murdock Study

Where it is running

• Carolinas Medical Center Northeast Medical Arts Building — Concord, North Carolina, United States
• Dermatology Group of the Carolinas — Concord, North Carolina, United States
• Ada Jenkins Center — Davidson, North Carolina, United States
• Harrisburg Sleep Center — Harrisburg, North Carolina, United States
• Lake Norman Community Health Clinic — Huntersville, North Carolina, United States
• Kannapolis Internal Medicine — Kannapolis, North Carolina, United States

Full record on ClinicalTrials.gov

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