Model for Heart Failure ExAcerbation Reduction Trial

Completed

Conditions studied: Acute on Chronic Heart Failure

In brief

Heart failure is the leading cause of hospitalizations and readmissions in the United States and is a tremendous economic strain on our healthcare system. There is currently, based on national averages, a 30% readmission rate and 10% mortality rate within 3 months of being hospitalized for heart failure. Retrospective studies have shown benefit to using biomarkers such as BNP to guide inpatient heart failure management. Our own CCF retrospective study showed that decreasing NT-ProBNP by 23%, making patients fluid negative by more than 1.3L, and discharging patients with serum sodium above 135 reduces readmission rates significantly. The purpose of this study is to prospectively use the above mentioned goals in the treatment of heart failure in order to reduce heart failure readmission and mortality rates.

Key facts

Study ID

NCT01726985

Run by

Cleveland Clinic Florida

People needed

230

Starts

2012-11-01

Expected to finish

2014-10-01

Last updated by the study team

2017-04-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Must have either Acute on Chronic Heart Failure or Chronic Heart Failure regardless of presenting/primary complaint
• To fulfill CHF Dx, MUST have 2+ of the following:
• Clinical: Dyspnea, orthopnea, PND, edema, S3, rales, improve w diuretics
• Radiographic: Pulm venous congestion, pleural effs, cardiomegaly
• Lab: NT pro BNP > 1000

You may not qualify if…

• None

Where it is running

• Cleveland Clinic Florida — Weston, Florida, United States

Full record on ClinicalTrials.gov

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