Green Vegetables and Women's Health

Completed · Not applicable · Has a placebo group

Conditions studied: Dietary Modification

In brief

The 2010 Dietary Guidelines for Americans recommend that individuals consume 4.5 to 5 cups fruits and vegetables daily. However, at current intake levels, fruit consumption will have to improve by more than 100% and vegetable intake by 50% to meet this recommendation. Importantly, intake of brightly colored fruits and vegetables is even lower when potatoes are not considered. It is possible that improved fruit and vegetable intake will have beneficial health effects. For example, higher intakes of fruits and vegetables, and particularly cruciferous vegetables (e.g., broccoli, Brussels sprouts, cauliflower, etc.), are associated with lower rates of many degenerative diseases, including some cancers, yet this group of vegetables may continue to be under-consumed due to their strong flavors. A supplement made from these vegetables (Cruciferous CompleteTM made by Standard Process Inc. Palmyra, WI) contains a group of phytochemicals called glucosinolates that can shift estrogen metabolism in a favorable way. One proposed biomarker of chemoprotection from breast cancer is the urinary estrogen metabolite ratio of 2- to 16α-hydroxyestrogens (2:16). In the main study, the effects of cruciferous vegetables (broccoli or Brussels sprouts), Cruciferous CompleteTM whole food supplements, or placebos on this ratio of urinary estrogen metabolites in healthy premenopausal women will be compared over an eight-week period. The investigators hypothesize that treatment with daily supplements will increase the 2:16 ratio as compared to daily consumption of a combination of Brussels sprouts and broccoli or a placebo, suggesting reduced breast cancer risk. In a sub-study, the relationships between serum α-carotene, β-carotene, β-cryptoxanthin, lutein and lycopene with dietary carotenoid intake as measured by a food frequency questionnaire and body composition will be evaluated in healthy premenopausal women. Carotenoids are a family of lipophilic compounds found primarily in colorful plant tissues and their concentration in human blood reflects dietary intake of carotenoid-rich foods. Carotenoid levels in the blood of healthy women do not appear to be influenced by menstrual status, but are inversely associated with body fatness. Thus, serum carotenoid concentrations may serve as a functional marker for chronic disease risk associated with excess body fat.

Key facts

Study ID

NCT01726127

Run by

University of Wisconsin, Madison

People needed

66

Starts

2012-11-01

Expected to finish

2015-09-01

Last updated by the study team

2015-10-07

Who can join

Age: 40 and older, up to 50. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Premenopausal women between the ages of 40-50; premenopause is defined as regular menstrual cycles every 23-35 days
• Willing to be randomized and compliant to the 3 study groups (whole cruciferous vegetable intake, cruciferous supplement or placebo capsules)
• Able to give informed consent.

You may not qualify if…

• Urinary 2:16 > or = 3.
• Current kidney or liver disease, adrenalectomy, or oophorectomy.
• Use of tobacco products within the preceding three months, illegal use of medications or use of illegal drugs or substances.
• Current use of antibiotics, cimetidine or black cohosh.
• Systemic administration of estrogen, or use of non-prescription hormones, tamoxifen, or diabetes medication within the last three months.
• Women under a physician-directed diet or those with a strong dislike of Brassica vegetables.
• Presence of cancer in the last 5 years, with the exception of fully resected basal or squamous cell tumors.
• Participation in an investigational drug study in the last 30 days.

Where it is running

• University of Wisconsin Osteoporosis Clinical Research Program Clinic — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.