Genetic Basis of Mitral Valve Prolapse

Status unconfirmed

Conditions studied: Mitral Valve Prolapse

In brief

The investigators have successfully identified two novel genetic loci for MVP on chromosomes 11 and 13 and are searching for altered genes in these regions. This requires recruiting large families who may have MVP linked to these or other chromosomes; and obtaining DNA samples from 1,000-1,500 individually affected patients to study the relation between DNA markers throughout the genome and MVP. It is our expectation that the results of this study will lead to the discovery of gene(s) responsible for MVP. This will lead to improved understanding of the disease and, in turn, improved ability to treat and prevent progression in genetically susceptible individuals.

Key facts

Study ID

NCT01719211

Run by

Massachusetts General Hospital

People needed

1500

Starts

1999-01-01

Expected to finish

2025-12-01

Last updated by the study team

2023-11-08

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Mitral valve prolapse

You may not qualify if…

• Other mitral valve diseases

Where it is running

• Mass General Hospital — Boston, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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