Improvement Assessment of Coronary Flow Dysfunction Using Fundamental Fluid Dynamics
Running, not enrolling
Conditions studied: Coronary Artery Disease
In brief
Diagnosis of relative contributions of large artery blockages and microvascular blockages is very much needed in the treatment of coronary artery disease. In order to achieve this, two novel parameters, pressure drop coefficient (CDP), which combines flow and pressure readings and Lesion flow coefficient (LFC), which combines anatomical details of the lesion with pressure and flow readings, are being investigated.
Key facts
- Study ID
- NCT01719016
- Run by
- University of Cincinnati
- People needed
- 68
- Starts
- 2010-08-01
- Expected to finish
- 2026-07-30
- Last updated by the study team
- 2026-05-07
Who can join
Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 18 years of age or above
- Patients referred to a stress test by a Cardiologist
- Acute Chest pain, as per patient input.
- Risk Assessment with prior test results and/or previous history of known chronic stable CAD.
- Borderline or discordant stress testing where obstructive CAD remains a concern.
- New or worsening symptoms- Abnormal coronary angiography or abnormal prior stress imaging study.
- Coronary stenosis or anatomic abnormality of uncertain significance.
- In absence of reliable diagnostic information from another imaging modality.
You may not qualify if…
- Left ventricular ejection fraction less the 25% determined by gated SPECT imaging
- Non-dialysis dependent chronic kidney disease with baseline serum creatinine greater than 2.5 gm/dL.
- History of type II heparin-induced thrombocytopenia.
- Significant co-morbid condition that is medically unstable and would make coronary angiography prohibitive or contraindicated.
- Pregnant women.
- Incapacitated for Consent
Where it is running
- Cincinnati Veteran Affairs Medical Center — Cincinnati, Ohio, United States
Full record on ClinicalTrials.gov
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