The Relationship Between Positive End Expiratory Pressure and Cardiac Index in Patients With Acute Respiratory Distress Syndrome (ARDS) Managed on a Fluid Protocol

Completed

Conditions studied: Acute Respiratory Distress Syndrome (ARDS)

In brief

The objective of this study is to evaluate the association between positive end-expiratory pressure (PEEP) setting and cardiac function, as measured by cardiac index, in patients with acute respiratory distress syndrome (ARDS) who were managed on the NHLBI ARDS Network Fluid and Catheter Treatment Trial (FACTT) fluid protocols.

Key facts

Study ID

NCT01714583

Run by

Yale University

People needed

367

Starts

2011-04-01

Expected to finish

2012-09-01

Last updated by the study team

2012-10-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Acute lung injury diagnosis (as defined by The American - European Consensus Conference on ARDS) of < 48 hours in duration.
• Patients in the Pulmonary Artery catheter (PAC) arm of the FACTT study. PaO2 / FiO2 ratio of < 200. Data from the first 3 days of mechanical ventilation.

You may not qualify if…

• Select chronic conditions that could independently influence survival (e.g., expected 6-month survival < 50%) and / or ventilator weaning.
• PEEP values missing. FiO2 values missing. PaO2 values missing. Cardiac index values missing Pressors and / or inotropes requirement.

Where it is running

• Yale University, School of Medicine, Department of Internal Medicine, Section of Pulmonary and Critical Care Medicine — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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