Does Tranexamic Acid Reduce the Need for Blood Transfusions in Patients Undergoing Hip Fracture Surgery?

Completed · Phase 4 · Has a placebo group

Conditions studied: Hip Fracture

In brief

Does tranexamic acid improve the perioperative care of those patients treated surgically for hip fracture by decreasing the proportion of patients requiring transfusion and decreasing total perioperative bleeding.

Key facts

Study ID

NCT01714336

Run by

Mayo Clinic

People needed

138

Starts

2012-09-01

Expected to finish

2015-10-01

Last updated by the study team

2018-11-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• AO/OTA (Orthopedic Trauma Association) fracture classification 31B
• Surgically treated with either hemiarthroplasty or total hip arthroplasty
• Acute fracture treated within 72 hours of injury
• Low energy isolated injury
• Age greater than 18 years old

You may not qualify if…

• Transfusion received during admission, prior to surgery
• Creatinine clearance less than 30 mL/min
• History of unprovoked Venous Thromboembolism (VTE) and/or recurrent VTE
• Known history of Factor V Leiden, protein C/S deficiency, prothrombin gene mutation, anti-thrombin deficiency, anti-phospholipid antibody syndrome, lupus anticoagulant
• Pregnancy or breastfeeding (pregnancy tests will be performed on all patients of child-bearing potential)
• History of cerebrovascular accident (CVA), Myocardial infarction (MI), or VTE within the previous 30 days
• Coronary stent placement within the previous 6 months
• Disseminated intravascular coagulation
• Subarachnoid hemorrhage

Where it is running

• Mayo Clinic in Rochester — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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