Human Brain Antioxidants During Oxidative Stress

Completed

Conditions studied: Oxidative Stress, Alzheimer's Disease, Aging

In brief

Antioxidants are important for having a good memory and for smart thinking when people get old, and that is important for everyone's quality of life. This research will find out if normal aging and Alzheimer's disease use up brain antioxidants. It will develop a new imaging tool that can help doctors to stop cognitive decline.

Key facts

Study ID

NCT01713816

Run by

University of Minnesota

People needed

52

Starts

2013-06-01

Expected to finish

2018-07-24

Last updated by the study team

2019-05-03

Who can join

Age: 65 and older, up to 89. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age and gender match to AD patients: age range 65-89:
• note that we anticipate that our patients will be predominantly male, so we are NOT likely to enroll females for this portion of the study
• Exclusion Criteria::
• Claustrophobia Implanted metal devices Pregnancy > RDA dietary supplements
• ≥ 5 F+V per day Smoking Depression Poor health or systemic illness Medial history of or evidence for cognitive problems Unstable medication usage Neurological problems Psychiatric disorder Substance abuse Usage of investigational drugs Inability to complete cognitive tests written in and calibrated for English speakers Inadequate vision or hearing to accommodate participation MMSE (dementia) score ≤ 26

Where it is running

• University of Minnesota — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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