Assessment of Sleep Apnea and Its Causes Before and After Weight Loss Surgery

Stopped early · Not applicable

Conditions studied: Sleep Apnea, Obstructive

In brief

The central aim of this research project is to determine how the ever-growing problem of obesity in the western world contributes to the pathophysiology of obstructive sleep apnea (OSA). To complete this aim, the investigators will determine the impact of obesity on the mechanisms underlying OSA. This will be achieved by making physiological measurements of 4 physiological traits known to cause OSA as well as the patients sleep apnea severity, before and after weight-loss surgery (i.e. bariatric surgery).

Key facts

Study ID

NCT01712269

Run by

Brigham and Women's Hospital

People needed

10

Starts

2012-10-01

Expected to finish

2017-01-01

Last updated by the study team

2017-03-03

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ages 18 - 65 years
• BMI > 35kg/m2
• Scheduled for weight-loss surgery

You may not qualify if…

• Previous history of bariatric surgery
• Any serious medical condition (except controlled hypertension and diabetes)
• Any sleep disorder except OSA (RLS, insomnia, etc.)
• Use of medications known to affect sleep/arousal, breathing, or muscle physiology
• Allergy to lidocaine or Afrin
• History of current cigarette smoking or previous smoking history >10 pack years

Where it is running

• Brigham and Women's Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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