Modeling Study to Predict Progression of Anal Cancer Pre-cursor Lesions in HIV

Status unconfirmed

Conditions studied: Neoplasms, Squamous Cell, Papillomavirus Infections

In brief

The purpose of this study is to determine whether a model can be created to predict the progression of early anal cancer precursor lesions in HIV using potential predictors such as: HIV treatment history, smoking history, sexual history, human papillomavirus viral load, human papillomavirus protein expression, and cell markers associated with progression of HPV-related lesions.

Key facts

Study ID

NCT01709448

Run by

National Institute of Allergy and Infectious Diseases (NIAID)

People needed

165

Starts

2009-01-01

Expected to finish

2014-03-01

Last updated by the study team

2012-10-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• HIV-infected
• Age > 18 years old
• Abnormal anal screening cytology

You may not qualify if…

• Inability to sign informed consent
• Life-threatening illness or other contraindication for high-resolution anoscopy
• anal intraepithelial neoplasia not confirmed by anal biopsy
• history of anal carcinoma
• history of HPV vaccination

Where it is running

• Cincinnati VA Medical Center — Cincinnati, Ohio, United States (enrolling)
• University of Cincinnati — Cincinnati, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

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