Peritoneal Dialysis vs Furosemide for Acute Kidney Injury After Cardiopulmonary Bypass

Completed · Not applicable

Conditions studied: Acute Kidney Injury

In brief

Acute kidney injury (AKI) after cardiopulmonary bypass (CPB) in infants is common and associated with poor outcomes. Peritoneal dialysis (PD) and furosemide have been used to attain negative fluid balance due to AKI induced oliguria, but have not been compared prospectively. The investigators will prospectively compare outcomes of infants with oliguria after CPB randomized to PD vs. furosemide with the hypothesis that infants receiving PD have superior outcomes.

Key facts

Study ID

NCT01709227

Run by

Children's Hospital Medical Center, Cincinnati

People needed

73

Starts

2011-10-01

Expected to finish

2015-06-01

Last updated by the study team

2017-06-09

Who can join

Age: any, up to 1. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age less than 6 months of age;
• Undergoing cardiothoracic surgery with CPB;
• Planned placement of PD catheter per institutional standard of care criteria.

You may not qualify if…

• Pre-existing chronic kidney disease stage 3 or above (correlating with estimated GFR<60 ml/min/m2, which will be calculated using routine preoperative serum creatinine value using the modified Schwartz equation).
• Known history of allergy to furosemide.

Where it is running

• Cincinnati Childrens Hospital Medical Center — Cincinnati, Ohio, United States

Full record on ClinicalTrials.gov

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