Sweat Evaporimeter Measurement

Completed · Not applicable

Conditions studied: Cystic Fibrosis

In brief

The investigators hypothesize that measurement of beta adrenergic induced sweat rate using an evaporimeter can accurately and reliably determine different levels of CFTR dysfunction within a spectrum of patients expressing various degrees of cystic fibrosis disease. The investigators overall goal is to determine whether the evaporimeter technique of measuring beta-adrenergic induced sweat rate is capable of accurately and reliably identifying different levels of CFTR dysfunction, as a prerequisite before advancing this technique as biomarker assay into clinical trials.

Key facts

Study ID

NCT01708655

Run by

University of Colorado, Denver

People needed

16

Starts

2011-12-01

Expected to finish

2014-12-01

Last updated by the study team

2014-12-03

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male or female ages 18 years and older.
• Subject with or without confirmed diagnosis of CF.
• Written informed consent obtained from subject.

You may not qualify if…

• Patients who are participating in clinical trials evaluating the safety, efficacy or clinical outcome of drugs that may alter the CFTR Cl channel function will be excluded.
• Any subject with a known hypersensitivity to any agonist used in the study or subjects receiving any drug (e.g. theophylline, antihypertensive agent) that might interfere with the investigations.
• Subjects with active dermatitis or other chronic skin condition such as psoriasis or a strong allergic history.
• Patients with a history of cardiac disease (including arrhythmias or hypertrophic obstructive cardiomyopathy).
• CF patients with severe malnutrition (BMI<18 kg/m2).
• CF patients with severe lung disease (FEV1<25%).
• Subject who has been treated for pulmonary exacerbation or other acute illness within one week of the study procedure.
• Any medical condition that, in the opinion of the investigator, will interfere with accurate conduct of the study.
• Subjects who are pregnant or lactating.
• Subject who is not able to stop inhalation therapy of β -adrenergic drugs 12 hrs before starting each test.

Where it is running

• Children's Hospital Colorado — Aurora, Colorado, United States

Full record on ClinicalTrials.gov

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