The Effect of Coffee on the Absorption of Thyroid Hormone in Patients With Thyroid Carcinoma
Withdrawn before enrolling · Not applicable
Conditions studied: Thyroid Carcinoma, Hypothyroidism
In brief
The purpose of this study is to evaluate whether taking thyroid hormone medication with beverages other than water, decreases absorption of the medication by the intestine. Specifically we are interested in whether coffee, coffee with milk, or black tea affects how thyroid medication is absorbed by the body. Previous studies have suggested that taking thyroid hormone with coffee may interfere with the ability to absorb thyroid medicine. Given that many patients take their thyroid medicine with beverages other than water, and specifically with coffee or tea, understanding whether and how much coffee or tea may decrease thyroid hormone absorption is important for clinical practice. This study will help determine the safest and most effective way for adults to take their thyroid medication and will guide medical practitioners in how to counsel their patients when they prescribe thyroid hormone.
Key facts
- Study ID
- NCT01707056
- Run by
- Medstar Health Research Institute
- People needed
- 0
- Starts
- 2012-09-01
- Expected to finish
- 2016-06-01
- Last updated by the study team
- 2021-02-17
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- patients with thyroid carcinoma after standard care of treatment on stable dose of Synthroid with a detectable baseline TSH
You may not qualify if…
- Pregnancy
- Undetectable baseline TSH
- Not willing to drink coffee, coffee with milk, or black tea
- Age less than 18 or greater than 60 years old
- Taking generic thyroid hormone (levothyroxine) and not brand-name Synthroid
- Dose of thyroid medication has been recently changed (less than 3 months ago)
- Currently receiving treatment for gastroesophageal reflux disease, gastritis, stomach or intestinal cancer, inflammatory bowel disease, or H. pylori
- Taking cholestyramine resin, colestipol hydrochloride, sucralfate, iron sulphate, aluminum containing antacids, activated charcoal, raloxifene, and herbal remedies
- History of previous gastric or small intestine surgery
- Diagnosis of kidney or liver disease, congestive heart failure, anemia, biliary disease, pancreatitis
Where it is running
- Georgetown University Hospital — Washington D.C., District of Columbia, United States
- Washington Hospital Center — Washington D.C., District of Columbia, United States
- MedStar St. Mary's Hospital — Leonardtown, Maryland, United States
Full record on ClinicalTrials.gov
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