Effect of Resistance Training on Tobacco-Related Cardiovascular Disease Risk

Status unconfirmed · Not applicable

Conditions studied: Smoking, Cardiovascular Disease Risk

In brief

This project is prompted by the urgent public health need to identify novel strategies to prevent and treat tobacco-related cardiovascular disease (CVD) and by compelling pilot data that suggests cessation of smoking results in rapid amelioration of endothelial function. The higher prevalence of CVD and metabolic syndrome in smokers have become major health care concerns. Therefore, finding optimal intervention strategies to combat these growing epidemics is imperative. We are investigating the efficacy of resistance training to ameliorate endothelial dysfunction, oxidative stress, inflammation, and insulin resistance in four groups: presence or absence of resistance training with or without cessation treatment + nicotine replacement. The investigators hypothesize that resistance training will improve cardiovascular function in smokers; however, the responses will be better in those who also stop smoking. In addition, resistance training will decrease smoking, however, the effects of counseling and nicotine replacement alone or counseling and nicotine replacement in conjunction with resistance training will be better than resistance training alone.

Key facts

Study ID

NCT01705951

Run by

University of California, Los Angeles

People needed

100

Starts

2011-04-01

Expected to finish

2013-12-01

Last updated by the study team

2012-10-12

Who can join

Age: 18 and older, up to 35. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Young Adults (18-35 yrs.)
• Male and female smokers
• Smokers (smoked at least one cigarette a day for 15 or more days in the last month and has smoked 100 cigarettes in life)
• 1-3 years experience consistently exercising/training at ≤2 days/wk of RT and ≤1 day/wk of aerobic exercise
• Capable of providing informed consent
• UCLA students/staff and Non UCLA student/staff
• Participant in good health as determined by baseline visit

You may not qualify if…

• Documented CAD
• Has had cardiac surgery
• Currently in weight loss or exercise program in the 6 months prior to participation.
• Use of medications that influence CV function or preclude the ability to train
• Syndromes or prescribed medications that may influence CVD, body composition, or insulin action (e.g. prednisone, Ritalin, Adderall, GH)
• Unable to exercise
• Diagnosed with syndromes or diseases that may influence body composition and CV risk (e.g. Cushing syndrome).
• Known heart arrhythmia and/or abnormalities found in electrocardiogram (ECG) reading that would prevent someone from performing the exercise intervention. If the subject demonstrates abnormal ECG during their pre-intervention visit (or any follow-up visit) the subject's ECG will be reviewed (for approval) by a cardiologist to continue in the study.
• Pregnant
• Use of hormonal contraceptives
• Currently in a smoking cessation program including use of NRT within the month of participation

Where it is running

• University of California, Los Angeles — Los Angeles, California, United States (enrolling)

Full record on ClinicalTrials.gov

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