Low Risk Acute Coronary Syndrome
Completed · Not applicable
Conditions studied: Low Risk Acute Coronary Syndrome
In brief
A large number of patients are diagnosed with low risk ACS, and these individuals are at significant cardiovascular risk. Though guidelines recommend stress testing to manage low risk ACS patients, evidence supporting this recommendation is not based on trials examining this population. A well-designed, randomized trial is warranted to determine if stress testing is useful in managing low risk ACS. If medical therapy alone is equivalent as the investigators hypothesize, healthcare expenditures could be reduced and patients may not be exposed to the harms associated with more invasive cardiac testing such as coronary angiography.
Key facts
- Study ID
- NCT01703156
- Run by
- University of Oklahoma
- People needed
- 70
- Starts
- 2009-05-01
- Expected to finish
- 2012-07-01
- Last updated by the study team
- 2017-04-12
Who can join
Age: 30 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- TIMI score < or = to 2(12)
- TIMI risk score of 3 with no known CAD, greater than 50% in one or more vessels
- Normal cardiac biomarkers (3 sets over 12-88 hours)
- No evidence of acute ischemia on electrocardiograms
- Normal ejection fraction (>40%) on echocardiography
- Age 30-75
- Ability to complete noninvasive stress test
- Ability to provide informed consent
You may not qualify if…
- Presence of another medical condition to explain chest pain or non-cardiac chest pain (i.e. pneumonia, costochondritis)
- Any patient who is initially classified as low risk but whom develops recurrent symptoms of ischemia, hemodynamic instability, or arrhythmias attributable to ischemia
- Evidence of ischemia on electrocardiogram
- Abnormal cardiac biomarkers
- History of medical noncompliance or social circumstances preventing compliance
- Life span estimated at <1 year
- Pregnancy
- Refusal to sign consent
Where it is running
- Veteran's Affairs Medical Center — Oklahoma City, Oklahoma, United States
Full record on ClinicalTrials.gov
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