Ovarian Stem Cells From Women With Ovarian Insufficiency
Completed
Conditions studied: Infertility
In brief
Background: \- Primary ovarian insufficiency (POI) is a condition that affects ovary function. It means that the ovaries are not able to function at a level appropriate for a woman's age. Previously, it was thought that women had only a fixed number of eggs that were lost each month until none were left at menopause. However, recently, stem cells have been found in the ovaries of adult women. These stem cells may be able to make new eggs. Studying these cells may help women with POI in the future. Researchers want to collect ovarian tissue from women with POI to investigate ovarian stem cells. Objectives: \- To collect ovarian tissue from women with primary ovarian insufficiency. Eligibility: \- Women between 18 and 50 years of age with primary ovarian insufficiency. Design: * Participants will be screened with a physical exam and medical history. They will also have a full gynecological exam. They will provide blood and urine samples. * Participants will donate ovarian tissue for study. It will be collected through outpatient surgery. The surgery will take either half of an ovary or a full ovary. * Treatment will not be provided as part of this study.
Key facts
- Study ID
- NCT01702935
- Run by
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- People needed
- 11
- Starts
- 2012-09-19
- Expected to finish
- 2017-09-21
- Last updated by the study team
- 2019-12-17
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
You may not qualify if…
- Unable to comprehend the investigational nature of the protocol participation
- Positive pregnancy test
- Anticoagulation or known coagulopathy
- Ovarian cancer
- History of a previous laparoscopy or laparotomy revealing abdominal adhesions that would preclude ovarian biopsy
- Previous bowel surgery.
Where it is running
- National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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