The Blood Pressure Effects of Febuxostat in Patients Previously Treated With Allopurinol: A Pilot Study

Stopped early · Not applicable

Conditions studied: Blood Pressure, Gout

In brief

Hyperuricemia (high uric acid level) has been correlated to hypertension (high blood pressure) and overall cardiovascular disease risk in several studies. The relationship has even been noted to be independent of metabolic syndrome and kidney function. It has been repeatedly noted that hyperuricemia was an independent risk factor of death in those at high cardiovascular disease risk. A recent review concluded that there is strong evidence that hyperuricemia and gout are coupled with atherosclerosis and cardiovascular events. Although this correlation of hypertension and hyperuricemia is known, there has only been one published study that has evaluated if lowering the uric acid would reduce the blood pressure. The authors concluded that in newly diagnosed hypertensive adolescents, allopurinol decreased the blood pressure. Despite this, further evaluation of this therapeutic approach has not been studied. The hypothesis of this study is that febuxostat, a new xanthine oxidase inhibitor, has blood pressure lowering effects superior to allopurinol in patients diagnosed with gout.

Key facts

Study ID

NCT01701622

Run by

University of Mississippi Medical Center

People needed

1

Starts

2010-01-01

Expected to finish

2011-10-01

Last updated by the study team

2018-01-12

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients currently treated at the University of Mississippi Medical Center General Internal Medicine/Hypertension or Family Medicine Clinics.
• Have a diagnosis of gout.
• Taking allopurinol at a stable dose for at least 2 months.

You may not qualify if…

• Less than 18 years old.
• Severe renal impairment defined as CrCl <30 mL/min.
• Previous diagnosis of severe hepatic impairment.
• Currently taking azathioprine, mercaptopurine, or theophylline.
• Pregnant, breastfeeding, or anticipating pregnancy or breastfeeding.
• Arm circumference greater than 50 cm.
• Change in antihypertensive medication within the previous 2 months.

Where it is running

• University of Mississippi Medical Center General Medicine/Hypertension and Family Medicine Clinics — Jackson, Mississippi, United States

Full record on ClinicalTrials.gov

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