Study to Find Optimal Dose of Local Spinal Anesthetic (Mepivacaine) Combined With Narcotic (Fentanyl) For Knee Surgery

Completed · Not applicable

Conditions studied: Arthroscopic Knee Surgery

In brief

Prolonged motor block and delayed ability to walk are limitations of spinal anesthesia in ambulatory (same-day) surgery. This can be improved by lowering the dose of local anesthetic (a medication that, when injected around nerves, blocks nerve conduction, resulting in numbness and weakness) used in the spine, but too low a dose can result in an incomplete block (inadequate anesthesia) in some patients. There is evidence that adding a low dose of fentanyl, a narcotic, to mepivacaine enhances the anesthetic effect. The purpose of this study is to determine the lowest dose of mepivacaine, a local anesthetic, when combined with fentanyl, for which spinal anesthesia is adequate for ambulatory knee arthroscopy.

Key facts

Study ID

NCT01701102

Run by

Hospital for Special Surgery, New York

People needed

56

Starts

2011-12-01

Expected to finish

2013-12-01

Last updated by the study team

2016-04-05

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Subjects aged 18-60
• Patients scheduled for "simple" knee arthroscopies, including meniscectomy, debridement, and plica.

You may not qualify if…

• Subjects aged <18 or >60
• Subjects greater than 190 cm in height
• Patients scheduled for ligament reconstruction or surgery involving bone
• Daily use of narcotics for greater than one week pre-op

Where it is running

• Hospital for Special Surgery — New York, New York, United States

Full record on ClinicalTrials.gov

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