Exercise, Statins, and the Metabolic Syndrome
Completed · Not applicable
Conditions studied: Metabolic Syndrome, Obese, Sedentary
In brief
Here we tested if statins or exercise plus statins had a greater capacity to lower metabolic syndrome risk factors in sedentary individuals with at least 2 metabolic syndrome risk factors. We also examined if statins impacted exercise response for mitochondrial content in muscle or aerobic fitness.
Key facts
- Study ID
- NCT01700530
- Run by
- University of Kansas Medical Center
- People needed
- 121
- Starts
- 2007-05-01
- Expected to finish
- 2011-05-01
- Last updated by the study team
- 2016-02-05
Who can join
Age: 25 and older, up to 59. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Sedentary metabolic syndrome subjects will be 25-59 y of age
- overweight to Class I or II obese (BMI 25-39 kg/m2) men and women
- 2 of 4 other characteristics of the metabolic syndrome including fasting glucose of 100 to 125 mg/dl; waist circumference greater than 102 cm in men and 88 cm in women, serum triglyceride concentration greater than 150 mg/dl, HDL-C concentrations less than 40 mg/dl in men and 50 mg/dl in women, and blood pressure greater than 130/85 mmHG
- Women must be taking birth control or be postmenopausal.
You may not qualify if…
- Diagnosed cardiovascular disease or diabetes or disease
- Symptoms that could alter their ability to perform exercise
- Fasting blood glucose of greater than 126 mg/dl
- Smoking
- Taking any medications or supplements (e.g., statins, fibrates, metformin, thiazolidenediones, anti-hypertensives (ACE-inhibitors and angiotensin blockers) which could affect blood lipids or insulin sensitivity.
- Women who are pregnant or plan to become pregnant during the duration of the study
- Individuals exercising regularly (more than one 30 min session per week)
- Individuals with an orthopedic limitations for walking.
- Report any allergies to the medications (statins, lidocaine)
Where it is running
- University of Missouri — Columbia, Missouri, United States
Full record on ClinicalTrials.gov
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