Consequences of Obstructive Sleep Apnea on Respiratory Function Following Weight-loss Surgery

Completed · Not applicable

Conditions studied: Obstructive Sleep Apnea, Obesity

In brief

The investigators propose to compare two different treatments, continuous positive airway pressure (CPAP) versus breathing of atmospheric pressure, in subjects with obstructive sleep apnea (OSA)recovering from weight loss surgery in the post anesthesia care unit (PACU). WE hypothesize that subjects with OSA will have a higher Apnea-Hypopnea Index (AHI) with desaturation and the investigators expect that post-operative CPAP treatment in the PACU will significantly improve the AHI and therefore improve patient safety in the PACU. The investigators also hypothesize that subjects with OSA have a greater decrease in oxygen saturation in response to opioid administration by patient-controlled opioid analgesia (PCA).

Key facts

Study ID

NCT01697878

Run by

Massachusetts General Hospital

People needed

45

Starts

2012-03-01

Expected to finish

2016-03-01

Last updated by the study team

2016-03-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• patients scheduled for weight loss surgery at Massachusetts General Hospital
• Male and female subjects
• age ≥ 18 years

You may not qualify if…

• CNS disease with impairment of cognitive function and/or muscle paresis such as stroke, or dementia
• age < 18 years
• missing or insufficient PSG data to make diagnosis OSA
• impaired decision making capacity

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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