Timing of Meal Insulin Boluses for Optimal Postprandial Glycemic Control in Type 1 Diabetes

Completed · Not applicable

Conditions studied: Type 1 Diabetes

In brief

Blood glucose levels in patients with type 1 diabetes tend to peak after eating a meal due to the delayed action of insulin when compared to carbohydrate absorption from food. It is the hypothesis of the investigator that administering the insulin for a meal 20 minutes before the meal will result in lower blood glucose peaks compared to administration of insulin immediately before or 20 minutes after starting to eat. All subjects will eat the same meal on three different occasions. Insulin will be administered at one of the three times at each visit.

Key facts

Study ID

NCT01693302

Run by

University of Colorado, Denver

People needed

23

Starts

2007-08-01

Expected to finish

2009-05-01

Last updated by the study team

2012-09-26

Who can join

Age: 12 and older, up to 30. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 12 to 30 years of age, inclusive
• Clinical diagnosis of T1D and using daily insulin therapy for at least 1 year
• Using carbohydrate counting to dose meal time insulin
• HbA1c value upon enrollment greater than 6.0% and less than 12.0%
• Using CSII therapy for diabetes management for at least three months
• Able and willing to give informed consent/assent to participate
• No expectation that the subject will be moving out of the area of the clinical center during the study
• Willing to consume the same standard frozen meal on all three visits

You may not qualify if…

• The presence of a significant medical disorder that in the judgment of the investigator will affect the wearing of the CGMS sensors or the completion of any aspect of the protocol
• Being unable or unwilling to give informed consent
• Having documented hypoglycemia unawareness
• An episode of severe hypoglycemia (seizure or loss of consciousness) or of ketoacidosis in the past six months

Where it is running

• Barbara Davis Center — Aurora, Colorado, United States

Full record on ClinicalTrials.gov

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