The Renin-Angiotensin-Aldosterone System and Parathyroid Hormone Control: The RAAS-PARC Study

Completed · Not applicable

Conditions studied: Hyperparathyroidism

In brief

This study will evaluate whether commonly used blood pressure medications called "ACE inhibitors" can lower parathyroid hormone.

Key facts

Study ID

NCT01691781

Run by

Brigham and Women's Hospital

People needed

41

Starts

2012-10-01

Expected to finish

2016-12-01

Last updated by the study team

2017-09-21

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy subjects with with no medical problems (n=15) and individuals with primary hyperparathyroidism (n=30)
• normal blood pressure or stage 1 hypertension that is either untreated, or adequately treated with a single anti-hypertensive medication.
• Age >18 years and <80 years
• Estimated GFR > 60ml/min

You may not qualify if…

• Chronic Kidney Disease or eGFR<60
• Stage 2 or Stage 3 hypertension or the use of more than 1 antihypertensive drug
• Type 2 Diabetes Mellitus that is not controlled by diet or Metformin alone or with a Hemoglobin A1c >7.5%
• History of liver failure
• History of heart failure
• The use of typical or atypical antipsychotic medications or lithium.
• Chronic inflammatory conditions (such as inflammatory bowel disease or arthritis) that are treated with prescribed doses of NSAIDs or glucocorticoids
• The use of prescribed doses of potassium supplements.
• Illness requiring overnight hospitalization in the past 6 months
• Active tobacco or recreational drug use
• Pregnancy or current breast feeding

Where it is running

• Brigham and Women's Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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