A Trial of Cranberry Capsules for Urinary Tract Infection Prevention in Nursing Home Residents

Completed · Phase 3 · Has a placebo group

Conditions studied: Bacteriuria

In brief

Urinary tract infection (UTI) is the most common infection in nursing home residents, and bacteriuria is the greatest trigger for antimicrobial therapy in the nursing home setting. The primary aim of this study is to test the efficacy of two oral cranberry capsules per day in the reduction of bacteriuria plus pyuria in female nursing home residents. These aims will be accomplished by conducting a double blind randomized placebo controlled efficacy trial of two oral cranberry capsules daily versus placebo in a cohort of Connecticut female nursing home residents.

Key facts

Study ID

NCT01691430

Run by

Yale University

People needed

185

Starts

2012-08-01

Expected to finish

2015-10-01

Last updated by the study team

2020-03-06

Who can join

Age: 65 and older. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• female residents;
• long term residents
• English speaking; and
• age ≥ 65 years.

You may not qualify if…

• residents that are not expected to be in the nursing home for at least one month (i.e., short term rehabilitation, pending discharge, terminal [life expectancy < 1 month]);
• residents who are on chronic suppressive antibiotic or anti-infective (i.e., mandelamine) therapy for recurrent UTI;
• residents with end stage renal disease on dialysis (they do not regularly produce urine);
• residents unable to produce a baseline clean catch urine specimen for collection;
• residents on warfarin therapy because of a potential interaction of warfarin and cranberry juice;
• residents with a history of nephrolithiasis because cranberry may increase the risk of nephrolithiasis;
• have an indwelling bladder catheter in place;
• have an allergy to cranberry products;
• are being treated with cranberry products;
• residence <4 weeks.

Where it is running

• Branford Hills Health Care — Branford, Connecticut, United States
• Northbridge Health Care Center — Bridgeport, Connecticut, United States
• Bridgeport Health Care Center — Bridgeport, Connecticut, United States
• Bridgeport Manor — Bridgeport, Connecticut, United States
• Riverside Health & Rehabilitation Center — East Hartford, Connecticut, United States
• Ludlowe Health Care Center — Fairfield, Connecticut, United States
• Glastonbury Health Care Center — Glastonbury, Connecticut, United States
• The Nathaniel Witherell — Greenwich, Connecticut, United States
• Arden House Care and Rehabilitation Center — Hamden, Connecticut, United States
• Hamden Health Care Center — Hamden, Connecticut, United States
• Avery Heights — Hartford, Connecticut, United States
• Wadsworth Glen Health Care and Rehabilitation Center — Middletown, Connecticut, United States
• Water's Edge Center for Health & Rehabilitation — Middletown, Connecticut, United States
• Grimes Center — New Haven, Connecticut, United States
• Mary Wade Home — New Haven, Connecticut, United States
• Advanced Nursing & Rehab Center of New Haven — New Haven, Connecticut, United States
• Shady Knoll Health Center — Seymour, Connecticut, United States
• Lord Chamberlain Nursing & Rehabilitation Center — Stratford, Connecticut, United States
• Village Green of Wallingford — Wallingford, Connecticut, United States
• Abbott Terrace Health Center — Waterbury, Connecticut, United States
• Hughes Health & Rehab Center — West Hartford, Connecticut, United States

Full record on ClinicalTrials.gov

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