COsegregation of VARiants in Panel of Genes
Recruiting now · Not applicable
Conditions studied: Gene Mutation-Related Cancer, Genetic Predisposition
In brief
The aim of the COVAR project is to achieve reliable classification of as many variants of interest as possible from the French OncoGenetics Database (FrOG, https://frog-db.fr/) in order to use them for the genetic counseling. The results obtained through this study will have a major impact on clinical management of the patients and their families conducting in some cases to propose a prophylactic surgery.
Key facts
- Study ID
- NCT01689584
- Run by
- Institut Curie
- People needed
- 11000
- Starts
- 2012-07-02
- Expected to finish
- 2038-01-02
- Last updated by the study team
- 2026-05-27
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Index cases:
- A person carrying a variant of interest in a gene analyzed in a diagnostic setting by one of the laboratories within the Genetics and Cancer Group (GGC)-Unicancer network, classified as class 3, 4 or hypomorphic class 5, and selected by the national expert group for the gene concerned.
- Age ≥ 18 years.
- Signed written inform consent "index case"
- Related parties:
- Any relative of an index case with cancer
- Any relative without cancer related to an index case, selected by the investigators, according to family structure and degree of related compared to the index case
- For class 4 and hypomorphic class 5 variants; relatives currently undergoing analysis or having already obtained a test result for the variant of interest as part of clinical care.
- Age ≥ 18 years
- Information and signature of the informed consent "selected relatives"
You may not qualify if…
- Minors
- Persons deprived of liberty or under guardianship (including curators).
- Absence of signed written inform consent
Where it is running
- Institut Paoli Calmettes — Marseille, France (enrolling)
- CHU La Timone — Marseille, France (enrolling)
- Institut Curie - Saint-Cloud site — Saint-Cloud, Haut de Seine, France (enrolling)
- Centre Hospitalier d'Angoulème — Angoulême, France (enrolling)
- Institut Sainte-Catherine — Avignon, France (enrolling)
- CHU Amiens - Hôpital Nord — Amiens, France (enrolling)
- Groupe Hospitalier Pellegrin — Bordeaux, France (enrolling)
- ICO - Centre Paul Papin — Angers, France (enrolling)
- Centre Hospitalier Jacques Coeur — Bourges, France (enrolling)
- CHU Morvan de Brest — Brest, France (enrolling)
- Centre François Baclesse — Caen, France (enrolling)
- Centre Hospitalier Hôtel Dieu — Chambéry, France (enrolling)
- Centre Jean Perrin — Clermont-Ferrand, France (enrolling)
- CHU Besançon — Besançon, France (enrolling)
- CHU de Dijon — Dijon, France (enrolling)
- CHU de Grenoble — Grenoble, France (enrolling)
- Institut Bergonié — Bordeaux, France (enrolling)
- Groupe Hospitalier La Rochelle-Ré-Aunis — La Rochelle, France (enrolling)
- Hôpital Flaubert — Le Havre, France (enrolling)
- Centre Oscar Lambret — Lille, France (enrolling)
- Chru Lille — Lille, France (enrolling)
- CHU Dupuytren — Limoges, France (enrolling)
- Hospices Civils de Lyon — Lyon, France (enrolling)
- Centre Léon Bérard — Lyon, France (enrolling)
- CHU Arnaud de Villeneuve — Montpellier, France (enrolling)
Full record on ClinicalTrials.gov
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