The Effect of Oral Vitamin D Versus Narrow-Band UV-B Exposure on the Lipid Profile

Completed · Not applicable

Conditions studied: Vitamin D Deficiency

In brief

Participants in this study will be randomized to receive either oral vitamin D pills OR ultraviolet light treatment. The investigators will compare how these two methods of raising vitamin D levels will affect cholesterol levels.

Key facts

Study ID

NCT01688102

Run by

Rockefeller University

People needed

118

Starts

2012-09-01

Expected to finish

2015-07-01

Last updated by the study team

2017-11-06

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age > 18 years
• Vitamin D 25-OH level < 20 ng/ml

You may not qualify if…

• Serum calcium > 10.5 mg/dl
• Serum phosphorus > 5.5 mg/dl
• Serum parathyroid hormone (PTH) level < 12 pg/ml
• LDL cholesterol > 190 mg/dl
• History of recent acute infection (within 1 month)
• Glomerular filtration rate(GFR) < 60 mL/min
• Liver Function tests indicative of liver disease (aspartate aminotransferase (AST) or alanine transferase (ALT) > 3x ULN)
• Current use of Vitamin D > 400 IU/day
• Current use of any statins, fibrates, niacin, or ezetimibe
• Current use of any medications affecting sensitivity to UV light
• Pregnancy (self-reported)
• Intentional UV exposure (e.g. tanning bed use) in the last 2 weeks or planned use while participating in the study
• history of malignancy not in remission (> 6 months)
• History of malignant melanoma
• Participation in an investigational drug study within 30 days of the screening visit
• Any medical, psychological or social condition that, in the opinion of the Investigator, would jeopardize the health or well-being of the participant during any study procedures or the integrity of the data.
• History of any non-melanoma skin cancer

Where it is running

• The Rockefeller University — New York, New York, United States

Full record on ClinicalTrials.gov

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