Omega-3 Fatty Acids and Insulin Sensitivity

Completed · Phase 3 · Has a placebo group

Conditions studied: Insulin Resistance

In brief

This study is being done to understand the effects of dietary omega-3 fats on insulin sensitivity in adult men and women.

Key facts

Study ID

NCT01686568

Run by

Mayo Clinic

People needed

31

Starts

2012-12-21

Expected to finish

2015-06-08

Last updated by the study team

2017-03-03

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18-65 years
• Insulin resistant (Homeostasis Model Assessment (HOMA) Insulin Resistance (IR) ≥2.6)

You may not qualify if…

• Current use of omega-3 nutritional supplements
• Fasting plasma glucose ≥126 mg/dL
• Active coronary artery disease
• Participation in structured exercise (>2 times per week for 30 minutes or longer)
• Smoking
• Medications known to affect muscle metabolism (e.g., beta blockers, corticosteroids, tricyclic-antidepressants, benzodiazepines, opiates, barbiturates, anticoagulants)
• Renal failure (serum creatinine > 1.5mg/dl)
• Chronic active liver disease (AST>144 IU/L and alanine transaminase (ALT)>165 IU/L)
• Anti-coagulant therapy (warfarin/heparin)
• International normalized ratio (INR) >3
• Use of systemic glucocorticoids
• Chronic use of NSAIDS or aspirin
• Pregnancy or breastfeeding
• Alcohol consumption greater than 2 glasses/day
• Hypothyroidism
• Fish or shellfish allergy

Where it is running

• Mayo Clinic in Rochester — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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