Attaining and Maintaining Wellness in Obsessive-compulsive Disorder

Completed · Not applicable · Has a placebo group

Conditions studied: Obsessive Compulsive Disorder

In brief

The goal of this study is to understand whether patients with obsessive-compulsive disorder (OCD) on serotonin reuptake inhibitors (SRIs) who receive a type of Cognitive-behavioral therapy called Exposure and Ritual Prevention (EX/RP) can discontinue their medication if they first do well with EX/RP.

Key facts

Study ID

NCT01686087

Run by

New York State Psychiatric Institute

People needed

137

Starts

2012-10-01

Expected to finish

2018-07-01

Last updated by the study team

2019-03-13

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Primary diagnosis of OCD
• Currently on a stable and adequate dose of a serotonin reuptake inhibitor (i.e., clomipramine, fluoxetine, fluvoxamine, sertraline, paroxetine, citalopram, escitalopram) but still have clinically significant OCD symptoms

You may not qualify if…

• Comorbid Psychiatric conditions that significantly elevate the risks of study participation (e.g. psychotic disorders, bipolar disorder, evidence of dementia or other cognitive disorder, suicidality)
• Unstable medical conditions that need attention and would make participation in the study unsafe (e.g., very high blood pressure)
• Patients who have already had prior adjunctive EX/RP (more than 8 sessions within 2 months) while receiving an adequate SRI trial
• Patients taking other medications besides an SRI (e.g. antipsychotics, mood stabilizers, other antidepressants besides SRIs)
• Patients who are pregnant, sexually active and not using contraception, or nursing
• Study Phase
• Inclusion Criteria:
• Those who achieve mild to minimum OCD symptoms from Preparatory Phase will enter the Study Phase
• Exclusion Criteria:
• All exclusions listed above for Preparatory Phase are exclusions for Study Phase as well
• Patients who are depressed at the end of the Preparatory phase are excluded from Study Phase

Where it is running

• New York State Psychiatric Institute — New York, New York, United States
• University of Pennsylvania Center for the Treatment and Study of Anxiety — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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