Occupational Therapy-Based Cognitive Rehabilitation of Cocaine Abusers: A Pilot Study

Completed · Not applicable

Conditions studied: Mild Cognitive Impairment, So Stated, Cocaine Use Disorder

In brief

This study integrates a model of occupational-therapy based cognitive rehabilitation as part of a comprehensive treatment plan for cocaine abusers. We hypothesize that cognitive impairment and quality of life would improve and that cocaine use would decrease in those participants receiving occupational-therapy based cognitive rehabilitation.

Key facts

Study ID

NCT01684293

Run by

University of California, San Francisco

People needed

50

Starts

2013-07-01

Expected to finish

2019-03-31

Last updated by the study team

2019-07-01

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18-65
• Primary cocaine use disorder (based on DSM-5 criteria) and in at least 3 months of remission
• At least mild cognitive impairment, defined as = or > 1.5 standard deviations impairment on any 2 performance-based neurocognitive measures
• Needing to change quality of life, defined as self-identifying at least 2 life areas as needing to change on the Drug User Quality of Life Scale
• A Veteran at the San Francisco Veterans Affairs Medical Center
• Currently receiving weekly drug counseling (individual or group; at least 1 hour/week) through an outpatient substance use disorder treatment program

You may not qualify if…

• Inability to speak, read, write, and understand English
• Inadequate hearing or vision
• Concurrent substance use disorder (except tobacco or caffeine) not in at least 3 months of remission
• A psychiatric disorder that will interfere with study participation or will make participation hazardous (e.g., psychosis, suicidal or homicidal ideations, severe anxiety)
• A depressive disorder classified as severe, defined as a Beck Depression Inventory-II score >29
• Current diagnosis of a bipolar disorder needing acute inpatient psychiatric hospitalization
• Currently symptomatic from attention-deficit/hyperactivity disorder (DSM-5 criteria)
• Any learning disorder, any type of dementia, any type of delirium, or an amnestic disorder due to any general medical condition
• Wechsler Test of Adult Reading standard score <70
• Mini-Mental State Examination score <24
• Current use of scheduled (i.e., prescribed) regular (i.e., daily) psychotropics or other medicines with a high likelihood of sedation \& cognitive impairment (e.g., benzodiazepines, clozapine, anticholinergics)
• Currently prescribed stimulants (e.g., methylphenidate) or cognitive enhancers (e.g., donepezil, memantine)
• Active medical illnesses - uncontrolled diabetes, uncontrolled hypertension, uncontrolled thyroid dysfunction, or uncontrolled B12/folate deficiency; central nervous system illness with potential cognitive aspects (Parkinson's, or Huntington's dementia); Cirrhosis with complications (e.g., ascites, encephalopathy, jaundice, gastrointestinal bleeding); Needing acute medical hospitalization from HIV sequelae, such as HIV-related opportunistic infection
• Any history of any type of stroke or brain hemorrhage
• Any history of traumatic brain injury, intracranial pathology (e.g., tumor), or brain surgery
• Currently on probation or parole
• Concurrent participation in another study that medically/administratively interferes with this study

Where it is running

• University of California, San Francisco & San Francisco Veterans Affairs Medical Center — San Francisco, California, United States

Full record on ClinicalTrials.gov

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