Use of Ultrasonography to Determine Fluid-responsiveness for Shock in a Population of Intensive Care Unit Patients

Running, not enrolling

Conditions studied: Hypotension

In brief

The objective of our study is to determine the correlation of transthoracic ultrasonographic indices of fluid responsiveness to changes in direct measures of cardiac output and to compare them to other established predictors of fluid responsiveness such as central venous pressure variation, systolic arterial pressure variation and pulse pressure variation in a broad population of patients. Hypothesis: There will be a significant difference in the inferior vena cava respiratory variation and subclavian vein respiratory variation between responders and non-responders to intravenous fluid challenge in a broad population of patients with shock.

Key facts

Study ID

NCT01680770

Run by

University of Chicago

People needed

124

Starts

2010-06-01

Expected to finish

2026-08-01

Last updated by the study team

2025-08-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients (> 18 years old) admitted to the intensive care unit.
• Decision by clinicians to give intravenous fluids for volume expansion.
• Decision by clinicians to obtain central venous access.

You may not qualify if…

• Patients with known chronic right heart failure syndromes.
• Patients with terminal conditions in whom aggressive care will not be pursued.
• Patients with a history of left bundle branch block.
• Patients will not be excluded on the basis of sex, race, or ethnicity.

Where it is running

• The University of Chicago Medical Center — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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