MRS Probe Study of Alcohol

Completed · Not applicable

Conditions studied: Heavy Dose Drinkers

In brief

This protocol will investigate the neurobiological underpinnings of alcohol craving in recently detoxified alcoholic drinkers utilizing novel functional brain imaging. This clinical magnetic resonance spectroscopy (MRS) study will investigate whether glutamate and other brain metabolites correlate to measures of alcohol craving severity

Key facts

Study ID

NCT01679444

Run by

Mayo Clinic

People needed

40

Starts

2012-08-01

Expected to finish

2014-06-01

Last updated by the study team

2014-06-30

Who can join

Age: 21 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• Inability to speak English
• Inability or unwillingness to provide written informed consent
• Diagnosis of active substance dependence other than nicotine (e.g. alcohol, cannabis, caffeine, prescription use of barbiturates, benzodiazepines, opiates, or stimulants) this will be determined using a PRISM (Psychiatric Research Interview for Substance and Mental Disorders) interview.
• Any unstable active medical or additional psychiatric condition as determined by the investigator
• Active suicidal ideation as determined by the PHQ-9 question 9 indicating response #2 or higher (several days; more than half the days; or nearly every day).
• History of encephalopathy, hepatic failure, or HIV seropositivity
• History of claustrophobia
• History of major head trauma with loss of consciousness >5 minutes or skull fracture
• History of previous neurological event (e.g. epilepsy, stroke, transient ischemic attack)
• Implanted metal objects (e.g. pacemakers; aneurysm clips; metal prostheses, joints, rods, or plates)
• Contraindication to MRI scanning
• Pregnancy or breast-feeding

Where it is running

• Mayo Clinic in Rochester — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.