A Phase 2 Study of siG12D LODER in Combination With Chemotherapy in Patients With Locally Advanced Pancreatic Cancer

Status unconfirmed · Phase 2

Conditions studied: Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer

In brief

In this Phase II study a dose of 2.8 mg (eight 0.35 mg siG12D-LODERs) will be administered in 12-week cycles to patients with unresectable or borderline resectable locally advanced pancreatic cancer combined with chemotherapy treatment. Primary Outcome: \- ORR at 6 months.

Key facts

Study ID

NCT01676259

Run by

Silenseed Ltd

People needed

80

Starts

2018-03-07

Expected to finish

2023-08-01

Last updated by the study team

2021-07-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age
• Subject must be 18 years of age or older at the time of signing the informed consent.
• Type of Subject and Disease Characteristics
• Histologically or cytologically confirmed adenocarcinoma of the pancreas.
• Locally advanced pancreatic cancer stage III according to The American Joint Committee on Cancer (AJCC) and defined as T4, N (any) and M0, according to the three factors, T (tumor), N (node involvement), and M (metastases), of the National Comprehensive Cancer Network TNM classification.
• Allocated to receive one of the following chemotherapies: gemcitabine plus nab-paclitaxel, FOLFIRINOX or modified FOLFIRIONOX as first line treatment for pancreatic cancer.
• Have a target tumor that is accessible for intratumoral administration by EUS as determined by the radiologist/gastroenterologist performing the EUS intratumoral administration, according to The American Society for Gastrointestinal Endoscopy (ASGE) guidelines (https://www.asge.org/home/practice-support/guidelines).
• Have measurable disease. Subject will have a histologically-confirmed disease and must have clinically and/or radiographically documented measurable primary disease according to RECIST v1.1. At least one site of disease must be unidimensionally measurable.
• Diagnostic Assessments
• Eastern Cooperative Oncology Group (ECOG) Performance Scale of ≤ 1.
• Demonstrate adequate organ function as defined below:
• serum creatinine <1.6 mg/dL
• international normalized ratio (INR) < 1.5 U
• absolute neutrophil count (ANC) > 1.5 x 109/L
• platelets ≥ 100 x 109/L
• hemoglobin ≥ 9 mg/dL
• alanine transaminase (ALT) and aspartate aminotransferase (AST) ≤ 5 times upper limit of normal (ULN)
• bilirubin ≤ 1.5 x ULN Sex
• Male and/or female. Contraceptive use by men or women should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.
• Women of childbearing potential (WOCBP): a negative serum or urine pregnancy test during screening.
• Subject of childbearing potential, if sexually active (both men and women) must agree to use a barrier method of contraception, from the time of administration of the first treatment and for at least 8 weeks after EOT visit day.
• Informed Consent
• Capable of giving signed informed consent which includes compliance with the requirements and restrictions listed in the informed consent form (ICF) and in this protocol.

You may not qualify if…

• Subjects are excluded from the study if any of the following criteria apply:
• Medical Conditions
• Subjects with resectable pancreatic cancer.
• Evidence of metastatic disease.
• Other malignancy that would interfere with the current intervention.
• Any evidence of ascites (beyond trace).
• Bulky celiac adenopathy (≥2.5 cm) or non-adenocarcinoma histology.
• Previously treated malignancies, except for adequately treated non-melanoma skin cancer, in situ cancer, or other cancers from which the subject has been disease-free for at least 2 years.
• History of clinically significant coagulopathy.
• Major surgery, other than diagnostic surgery, within 4 weeks prior to study entry without complete recovery.
• New York Heart Association (NYHA) Class III or IV, cardiac disease, myocardial infarction within 4 months prior to the first chemotherapy cycle Day 1, unstable arrhythmia or symptomatic peripheral arterial vascular disease.
• Active, uncontrolled bacterial, viral, or fungal infections, requiring systemic therapy.
• Known active infection with human immunodeficiency virus (HIV), hepatitis B virus, or hepatitis C virus.
• Females who are pregnant or breast-feeding.
• Concomitant disease or condition that could interfere with the conduct of the study, or that would, in the opinion of the Investigator, pose an unacceptable risk to the subject in this study.
• Prior/Concomitant Therapy
• Any prior therapy for the treatment of pancreatic malignancy (including chemotherapy, immunotherapy, vaccines, monoclonal antibodies, major surgery, or irradiation, whether conventional or investigational).
• Prior therapy with any hypoxic cytotoxic agent (hypoxia-targeting drugs). Prior/Concurrent Clinical Study Experience
• Subjects who are participating or participated in an investigational drug or device study (within 28 days prior to study entry from the last study dose date).
• Other Exclusions:
• Unwillingness or inability to comply with the study protocol for any reason.
• Known allergy to sesame oil.

Where it is running

• Sheba Medical Center (Tel H'shomer) — Ramat Gan, Israel (enrolling)
• Sourasky MC (Ichilov) Tel Aviv Israel — Tel Aviv, Israel (enrolling)
• Memorial Sloan Kettering Cancer Center — New York, New York, United States (enrolling)
• MD Anderson Cancer Center — Houston, Texas, United States (enrolling)
• Rambam Medical Center — Haifa, Israel (enrolling)
• The Mount Sinai Hospital — New York, New York, United States (enrolling)
• Assaf Harofeh Medical Center — Tzrifin, Israel
• Rabin Medical Center — Petah Tikva, Israel
• Hackensack Meridian Health — Hackensack, New Jersey, United States

Full record on ClinicalTrials.gov

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