Association Between Body Size and Response to Hydromorphone in ED

Completed · Phase 2

Conditions studied: Pain

In brief

Pain is the most common complaint for patients presenting to the emergency department (ED). Inadequate pain relief is also a common problem in ED. Patients' pain perceptions and responses to intravenous opioids vary widely and are influenced by multiple factors. The objective of the current study is to examine the association between total body weight, BMI (body mass index) and clinical response to a fixed dose of intravenous hydromorphone.

Key facts

Study ID

NCT01675778

Run by

Albert Einstein College of Medicine

People needed

174

Starts

2011-10-01

Expected to finish

2012-12-01

Last updated by the study team

2020-10-08

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• English or Spanish speaking
• Age 18 - 65 years old
• Acute pain (less than 7 days in duration)
• Pain with sufficient severity to warrant use of intravenous opioids in the judgment of ED attending physician

You may not qualify if…

• Allergy to hydromorphone
• Systolic blood pressure < 90 mm Hg
• Room air oxygen saturation by pulse oximetry < 95% at baseline without supplemental oxygen
• Alcohol or other drug intoxication as judged by the attending physician
• Suspicion of drug seeking by ED physician
• Use of opioids within the past 24 hours
• Use of a monoamine oxidase inhibitor
• Concurrent use of benzodiazepines
• Presence of a chronic pain syndrome (such as sickle cell disease, peripheral neuropathy, diabetic neuropathy, or fibromyalgia)
• History of COPD, sleep apnea, renal failure, liver disease
• Pregnancy or breast feeding
• Prior entry of patient in the study
• Inability or unwillingness to provide informed consent

Where it is running

• Jacobi Medical Center — The Bronx, New York, United States
• North Central Bronx Hospital — The Bronx, New York, United States

Full record on ClinicalTrials.gov

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