Role of Nox2 in CNI-induced Renal Fibrosis

Completed

Conditions studied: Kidney Disease

In brief

Calcineurin Inhibitors (CNI) are drugs used to suppress the immune system when a person has a solid organ transplant. Although these drugs keep the transplanted organ from being rejected they are toxic to kidneys, or nephrotoxic. CNIs cause damage, called fibrosis, to kidneys. Fibrosis is a type of scarring that occurs in kidney tissue. Fibrosis can eventually lead to kidney failure. One of the pathways that cause fibrosis is a chronic lack of oxygen to the kidney tissue called "hypoxia". There is a protein called Nox2 that may be involved in how this hypoxia happens in the kidney. The Department of Medicine-Nephrology at the University of Wisconsin is conducting a research study to see how much of the Nox2 protein is present in kidneys that may have fibrosis caused by CNIs and whether a certain type of Magnetic Resonance Imaging (MRI) can be used to tell in advance if the disease caused by CNIs is getting worse. Study hypothesis: MRI, a non-invasive technique, can be used to determine whether CNI induced kidney disease is getting worse. Additionally, the study aims to determine the role of Nox2 in CNI nephrotoxicity.

Key facts

Study ID

NCT01674465

Run by

University of Wisconsin, Madison

People needed

8

Starts

2012-11-30

Expected to finish

2019-10-10

Last updated by the study team

2019-10-14

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• liver, heart, lung or pancreas transplant recipients
• suspected CNI induced nephrotoxicity

You may not qualify if…

• minors
• pregnant women
• prisoners
• institutionalized individuals or other vulnerable groups
• history of allergic reactions or adverse reactions to Pimonidazole
• Claustrophobia
• hazardous metallic implants
• cardiac pacemakers

Where it is running

• Wisconsin Institute for Medical Research (WIMR) — Madison, Wisconsin, United States
• University of Wisconsin Hospital and Clinics — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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