The Effects Grapes on Health Indices
Completed · Not applicable · Has a placebo group
Conditions studied: Obesity, Inflammation, Cardiovascular Disease, Oxidative Stress
In brief
The investigators hope to learn about the effects of whole grapes, in the form of freeze-dried grape powder, on markers of health. Phytochemical rich food consumption is associated with protection against chronic diseases such as cardiovascular disease (CVD) demonstrating the ability to modify endothelial function and lipemia, but exact causal mechanisms are still not well understood. The investigators will examine metabolic and mechanistic effects of consumption of whole grape powder in chronic as well as acute settings in response to meal challenges by testing blood samples to determine if markers of health have improved. The central hypothesis of this project is that consumption of grapes in the form of a polyphenol-rich freeze-dried whole grape powder (WGP) will attenuate chronic and meal induced oxidative stress and inflammatory responses in obese individuals.
Key facts
- Study ID
- NCT01674231
- Run by
- University of California, Davis
- People needed
- 20
- Starts
- 2012-08-01
- Expected to finish
- 2015-04-01
- Last updated by the study team
- 2017-05-30
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Men and women 18 years of age or older in good health
- BMI >30
You may not qualify if…
- Smokers
- Chronic disease, such as diabetes, cancer, and renal, liver or thyroid dysfunction
- History of gastrointestinal disease
- History of cardiovascular events
- If pregnant or lactating
- Regular users of statin drugs, aspirin, anti-inflammatory medications, antioxidants or botanical supplements
- Allergy to grapes
Where it is running
- Ragle Human Nutrition Center — Davis, California, United States
Full record on ClinicalTrials.gov
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