Sucrose Breath Test to Determine Intestinal Permeability in IBS

Completed

Conditions studied: Irritable Bowel Syndrome

In brief

Irritable Bowel Syndrome (IBS) is a growing clinical diagnosis affecting 10-20% of the US population. While current diagnostic criteria aids in correctly diagnosing IBS, the cause of the disease still remains unclear. It has been hypothesized that patients with IBS have alterations in the intestinal lining leading to release of toxic substances into the blood, commonly referred to as leaky gut. Current methods used to study leaky gut are both expensive and invasive. The investigators will test a new breath test to measure leaky gut in both IBS patients and subjects without IBS symptoms.

Key facts

Study ID: NCT01674088
Run by: Metabolic Solutions Inc.
People needed: 40
Starts: 2012-10-01
Expected to finish: 2013-01-01
Last updated by the study team: 2014-02-10

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Male or females with clinical diagnosis of Irritable Bowel Syndrome by Rome III criteria (IBS Group) or healthy control.
Must be 18 years old or greater.
Women of child-bearing potential must have a negative pregnancy test.

You may not qualify if…

Females who are lactating or pregnant.
Subjects with allergy to sucrose.
Subjects with other causes of abdominal pain or altered bowel habits such as IBD, celiac disease, pancreatitis or gastrointestinal bleeding.
Subjects with a history of diabetes mellitus.
Subjects with a recent febrile illness (5 days prior to study).
Subjects that received an investigational drug or device within 30 days prior to study entry.
Subjects that do not have the mental capacity to understand the protocol.

Where it is running

University of Florida Shands Hospital — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

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