Prevention of Stimulant-Induced Euphoria With an Opioid Receptor Antagonist

Completed · Phase 4 · Has a placebo group

Conditions studied: ADHD, Stimulant-Induced Euphoria

In brief

The purpose of this study is to a) assess the efficacy of naltrexone in preventing stimulant-induced euphoria in adults with ADHD, b) assess whether naltrexone will interfere with the clinical efficacy of stimulants in treating adults with ADHD, c) assess whether naltrexone will interfere with the effects of stimulants on neurotransmitter activity. We predict that naltrexone will successfully prevent stimulant-induced euphoria without interfering with the ability of stimulants to effectively treat ADHD in adults. This study will be an 8 -week trial with young adults (18-24) with ADHD.

Key facts

Study ID
NCT01673594
Run by
Massachusetts General Hospital
People needed
37
Starts
2012-09-01
Expected to finish
2015-06-01
Last updated by the study team
2016-11-30

Who can join

Age: 18 and older, up to 30. Sex: any. Healthy volunteers: not accepted.

Where it is running

Full record on ClinicalTrials.gov

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