Stress Biomarkers:Attaching Biological Meaning to Field Friendly Salivary Measures

Completed · Phase 1

Conditions studied: Stress

In brief

Cortisol is a stress hormone that can be measured in saliva. This has provided a convenient way to evaluate the biological impact of day-to-day stressors that people encounter as they go about their lives, since saliva is so easy to collect. However, the biological meaning of saliva cortisol measures has never been carefully examined. The goal of this study is to collect saliva from a large group of people as they go about their every-day lives, to measure their cortisol levels, and then study them in the laboratory where Investigators can learn more about how their stress response system (which produces cortisol) is really functioning. Investigators can then determine much more precisely what saliva cortisol levels really mean in terms of stress system biology. This will allow investigators to obtain much more useful information from the next decade of research on naturalistic stress and its biological impact using saliva cortisol measures, helping investigators to understand how stress undermines health and how to combat this effect.

Key facts

Study ID

NCT01673087

Run by

University of Michigan

People needed

256

Starts

2012-10-01

Expected to finish

2017-08-15

Last updated by the study team

2018-04-23

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Medically healthy volunteers, ages 18 to 50 years

You may not qualify if…

• Pregnancy
• Irregular menses, medications or drugs that effect HPA axis
• Most psychiatric disorders
• Medical problems that effect HPA axis or increase risks involved in participation

Where it is running

• University of Michigan Health System — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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