Discovery and Validation of Proteogenomic Biomarker Panels in Liver Transplant Recipients
Completed
Conditions studied: Liver Transplant Recipients, Liver Transplantation
In brief
The main focus of this study is to develop blood and/or urine tests that will help to detect early signs of rejection in people who have had a liver transplant. Researchers will examine blood, urine, and tissue samples and try to identify markers for certain conditions such as rejection, response to therapy, and scarring of the liver. Additionally, researchers would like to identify biomarkers that can detect damage to the native kidneys before blood levels of creatinine rises. By studying gene expression, researchers hope to be able to diagnose these conditions earlier and improve liver survival.
Key facts
- Study ID
- NCT01672164
- Run by
- National Institute of Allergy and Infectious Diseases (NIAID)
- People needed
- 202
- Starts
- 2012-08-01
- Expected to finish
- 2015-12-01
- Last updated by the study team
- 2016-09-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Subjects undergoing primary deceased-donor or living donor liver transplantation;
- Subject must be able to understand and provide informed consent.
You may not qualify if…
- Need for combined organ transplantation;
- Previous solid organ and/or islet cell transplantation;
- Infection with HIV;
- Allergy to iodine;
- Inability or unwillingness of a participant to comply with study protocol;
- Any condition that, in the opinion of the investigator, would interfere with the participant's ability to comply with study requirements.
Where it is running
- Mayo Clinic — Phoenix, Arizona, United States
- Northwestern University, Feinberg School of Medicine — Chicago, Illinois, United States
- Mount Sinai School of Medicine — New York, New York, United States
- Cleveland Clinic Foundation — Cleveland, Ohio, United States
- Medical University of South Carolina — Charleston, South Carolina, United States
- Baylor University Medical Center — Dallas, Texas, United States
Full record on ClinicalTrials.gov
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