Mechanisms of Chronic Kidney Disease (CKD)-Induced Foam Cell Formation
Completed
Conditions studied: Chronic Kidney Disease, Cardiovascular Disease
In brief
There is currently little understanding of macrophage cholesterol homeostasis and foam cell formation across the spectrum of CKD. We hypothesize that an inverse relationship exist between the severity of CKD and processes underlying foam cell formation, and that the relationship becomes independent of serum lipoprotein levels as renal function declines. We propose to systematically examine scavenger receptors and cholesterol uptake as well as cholesterol transporters and efflux mechanisms in individuals with normal renal function, patients with moderate CKD. We further propose to determine if processed contributing to foam cell formation are related to the plasma lipid profile and if the relationship is modified by co-morbidities, such as diabetes, obesity, systemic inflammation which are common in this population and directly influence vascular integrity. These data will be critically important to understand when the abnormality starts and will provide crucial information.
Key facts
- Study ID
- NCT01671605
- Run by
- Vanderbilt University Medical Center
- People needed
- 103
- Starts
- 2013-02-01
- Expected to finish
- 2015-04-01
- Last updated by the study team
- 2017-04-21
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients with moderate degree of CKD, or patients with advanced CKD or control subjects with intact kidney function
- Male or female
- All ethnic groups
- ≥ 18 years and have signed informed consent
You may not qualify if…
- Pregnancy and current smoking
- BMI > 45
- Rheumatoid arthritis and systemic lupus erythematosus
- History of active or chronic hepatitis B, history of active or chronic hepatitis C, human immunodeficiency virus (HIV)
- For moderate CKD subjects: nephrotic syndrome
- For control subjects: nephrotic syndrome, patients with estimated GFR < 60 mL/min/1.73 m\^2, or proteinuria
Where it is running
- Vanderbilt Outpatient Dialysis Center — Nashville, Tennessee, United States
Full record on ClinicalTrials.gov
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