Effects of Dark Chocolate on Exercise Capacity, and Mitochondrial Structure and Function

Completed · Not applicable · Has a placebo group

Conditions studied: Heart Failure, Type 2 Diabetes

In brief

The major goal of this study is to characterize the ability of dark chocolate enriched in epicatechin (a component of dark chocolate) to improve the structural and functional features of mitochondria in two groups 1. Patients with heart failure (HF) and type 2 diabetes (DM2) and 2. Normal yet sedentary individuals with impaired baseline exercise capacity (as assessed by VO2 max) We propose that a 3 month treatment with dark chocolate will lead to a significant improvement in exercise capacity which will be secondary to the improvement in skeletal muscle structure from epicatechin.

Key facts

Study ID

NCT01671514

Run by

University of California, San Diego

People needed

21

Starts

2012-07-01

Expected to finish

2014-12-01

Last updated by the study team

2015-06-03

Who can join

Age: 40 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy, inactive individuals
• BMI 27-32

You may not qualify if…

• Smoking or quit smoking less than 1 year prior to enrollment
• Currently taking Coumadin or Pradaxa.
• Heart failure and diabetes patients:
• Inclusion Criteria:
• Medically diagnosed with heart failure and diabetes
• No significant HbA1C fluctuations in past 6 months
• Exclusion Criteria:
• Currently taking Insulin
• Currently taking Coumadin or Pradaxa.
• Smoking or quit smoking less than 1 year prior to enrollment

Where it is running

• University of California, San Diego — La Jolla, California, United States

Full record on ClinicalTrials.gov

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