ATS907 Ph2a Open-Label Dose-ranging Safety and Tolerability in Primary Open Angle Glaucoma (POAG) and Ocular Hypertension (OHT) Subjects
Completed · Phase 2
Conditions studied: Primary Open Angle Glaucoma, Ocular Hypertension
In brief
This single-site, dose-escalation study will evaluate safety and tolerability of increasing concentrations of ATS907 in 12 subjects with Primary Open Angle Glaucoma and/or Ocular Hypertension
Key facts
- Study ID
- NCT01668524
- Run by
- Altheos, Inc.
- People needed
- 12
- Starts
- 2012-08-01
- Expected to finish
- 2012-08-01
- Last updated by the study team
- 2012-09-07
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 18 years of age or greater
- Diagnosis of open angle glaucoma or ocular hypertension in both eyes
- Corrected visual acuity in each eye +1.0 logMAR or better by Early Treatment Diabetic Retinopathy Study (EDTRS) in each eye (equivalent to 20/200)
- Must be willing to discontinue the use of all ocular hypotensive medications in both eyes prior to and during the entire course of the study
You may not qualify if…
- Ophthalmic (in either eye):
- Glaucoma: pseudoexfoliation, steroid induced, pigment dispersion glaucoma, and or history of angle closure. Previous glaucoma intraocular surgery or glaucoma laser procedures in study eye(s). Refractive surgery in study eye
- Cataract surgery and or other intraocular surgery within one month prior to Screening in either eye
- History within 3 months prior to Screening of clinically significant moderate or severe chronic or active ocular infection, inflammation, blepharitis, dermatitis, uveitis or conjunctivitis
- Clinically significant corneal dystrophy, epithelial and or endothelial disease, corneal irregularities and or scarring such that reliable applanation tonometry would prevented
- Contact lens wear during the duration of the study
- Clinically significant ocular disease (e.g., diabetic retinopathy, macular degeneration, or uveitis) which might interfere or progress during the study
Where it is running
- Sall Research Medical Center — Artesia, California, United States
Full record on ClinicalTrials.gov
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