Efavirenz and Ritonavir on Human Brain P-Glycoprotein

Completed · Phase 1/Phase 2

Conditions studied: Drug Effects

In brief

To determine the effects of ritonavir and efavirenz on the activity of P-glycoprotein in human brain.

Key facts

Study ID

NCT01668147

Run by

Washington University School of Medicine

People needed

13

Starts

2012-08-01

Expected to finish

2016-08-01

Last updated by the study team

2020-01-22

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male or non-pregnant female, 18-40 yr old
• Good general health with no remarkable medical conditions
• BMI < 33
• Provide informed consent

You may not qualify if…

• Known history of liver or kidney disease
• History of major medical conditions
• HIV seropositive
• Fasting blood glucose > 110 mg/dl
• Family history of type 2 diabetes
• Use of prescription or non prescription medications, herbals or foods known to be metabolized by or altering P-glycoprotein or CYP3A activity (hormonal birth control medications are acceptable if alternative means of contraception are used)
• Females who are pregnant or nursing
• Females taking hormonal contraceptives who are unwilling to use alternative means of contraception
• Contraindications to MRI
• Contraindications to PET scanning

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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