Study of Sulfasalazine in Treating Painful Neuropathy

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Painful Neuropathy

In brief

The investigators hypothesize that sulfasalazine, an FDA-approved medication for rheumatoid arthritis and ulcerative colitis, may be beneficial in neuropathic pain conditions. In this study, the investigators will evaluate whether sulfasalazine improves pain due to painful peripheral neuropathy.

Key facts

Study ID

NCT01667029

Run by

Massachusetts General Hospital

People needed

8

Starts

2013-05-01

Expected to finish

2017-08-10

Last updated by the study team

2018-08-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Painful neuropathy
• Michigan Neuropathy Screening Instrument score of 3 or greater
• no obvious alternative explanation for neuropathy
• average baseline pain > 4/10

You may not qualify if…

• other severe pain
• anticipated difficulty weaning off medications
• past or current psychiatric disorder as determined by Mini International Neuropsychiatric Interview
• medical contraindication to sulfasalazine
• not proficient in English (due to heavy use of questionaires)
• pregnant or breast feeding women

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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