The Metabolomics of Anaphylaxis
Withdrawn before enrolling
Conditions studied: Patients With AERD Undergoing Aspirin Desensitization
In brief
Metabolomics is the study of metabolic pathways and the unique biochemical molecules which result from the regulatory response to physiological stressors, disease processes, or drug therapy. By measuring changes in metabolite concentrations, the range of biochemical effects and therapeutic intervention can be determined. Aspirin exacerbated respiratory disease (AERD) is a chronic inflammatory disease characterized by chronic rhinosinusitis, nasal polyposis, asthma, and airway reactivity to aspirin and/or other nonsteroidal anti-inflammatory drugs (NSAIDs). This reaction to aspirin during challenge/desensitization is equivalent to an allergic drug reaction however we are able to evaluate these specific reactions in a controlled, clinical environment. This population of patients undergoing aspirin desensitization is ideal for studying metabolomics as serial blood sampling can be performed in patients before, during a reaction, and after aspirin desensitization, thereby allowing each patient to serve as his or her own biological control. The investigator hopes that this study of metabolomics will allow for better methods of identifying anaphylaxis in the future.
Key facts
- Study ID
- NCT01666275
- Run by
- Massachusetts General Hospital
- People needed
- 0
- Starts
- 2012-03-01
- Expected to finish
- 2018-08-14
- Last updated by the study team
- 2019-03-07
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients ages 18-75 with a history of aspirin anaphylaxis or a history of hypersensitivity reaction to aspirin and referred for a clinically indicated outpatient or inpatient aspirin desensitization procedure for AERD.
You may not qualify if…
- Pregnancy/breastfeeding, possibility of poor compliance, unwilling to undergo aspirin desensitization.
Where it is running
- Massachusetts General Hospital - Allergy Associates — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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