Neural, Behavioral and Physiological Correlates of Feeding in Humans

Completed

Conditions studied: Magnetic Resonance Imaging, Functional

In brief

The overarching goal of this project is to understand how nicotine addiction interacts with feeding behaviors and brain representation of food reward. The current proposal is part of a larger effort to begin a program of research to elucidate similarities and differences in perception of, and behavioral and neural response to, food and cigarette aromas as a function of 1) smoking status (smokers, ex-smokers who do gain weight, ex-smokers who do not gain weight, non-smokers), 2) internal state (hungry, full), and 3) cigarette deprivation (acute, chronic). A general hypothesis is that there are overlapping neural mechanisms governing food reward and cigarette reward in smokers and that this overlap includes incentive salience encoding.

Key facts

Study ID

NCT01665560

Run by

Yale University

People needed

27

Starts

2005-06-01

Expected to finish

2009-07-01

Last updated by the study team

2012-08-15

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy
• between the ages of 18-45
• fMRI safe

You may not qualify if…

• outside of the above age range
• not able to have an fMRI (non-removable metal, pacemaker, etc)
• medical diagnosis related to neurological problems, anxiety, psychiatric conditions
• Did not refrain from smoking for the described time in the smoking group, or showed a CO2 level consistent with a smoker in the non-smoking group

Where it is running

• John B Pierce Laboratory — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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