Nicotine Dependence, Withdrawal and Replacement Therapy Assessed by PET Imaging

Completed · Phase 4 · Has a placebo group

Conditions studied: Nicotine Dependence

In brief

The proposed research will provide significant new gender-specific information of scientific and clinical relevance on the function of the mu-opioid system in nicotine dependence and therapeutic effectiveness of nicotine replacement therapy (NRT). The studies will help to explain the differences in the prevalence of smoking in men and women, sex-specific differences in nicotine craving and withdrawal as well as the poorer therapeutic response to NRT. This work may pave the way to the design of improved pharmacotherapies that can more effectively target the endogenous opioid system in the treatment of nicotine dependence.

Key facts

Study ID

NCT01664741

Run by

Johns Hopkins University

People needed

127

Starts

2012-04-01

Expected to finish

2018-12-01

Last updated by the study team

2019-05-09

Who can join

Age: 21 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 21 - 60 years old
• must meet DSM-IV criteria for nicotine dependence and be actively smoking
• Exclusion Criteria: subjects must meet study guidelines for medical and mental health status.

Where it is running

• Johns Hopkins University School of Medicine — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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