Sequence of Symptom Change During AUD or PTSD Treatment for Comorbid PTSD/AUD

Status unconfirmed · Not applicable

Conditions studied: PTSD, Alcohol Abuse, Alcohol Dependence

In brief

The broad, long-term objective of the current research is to improve treatment outcomes for individuals with comorbid posttraumatic stress disorder (PTSD) and alcohol abuse and dependence (AUD). The purpose of which is to evaluate changes in both PTSD symptoms and alcohol use and cravings associated with Cognitive Processing Therapy (CPT) or Relapse Prevention (RP) treatment in individuals with PTSD/AUD, along with mediators and moderators of outcomes. The study will randomize 235 PTSD/AUD participants recruited from the VA and from the community to CPT, RP, or Interactive Voice Response (IVR) assessment only (AO). Those in the AO condition will be re-randomized after the treatment phase to either RP or CPT. Individuals will be assessed pretreatment, immediately post-treatment, 3-, 6-, 9-, and 12-months post-treatment and will monitor symptoms daily throughout treatment.

Key facts

Study ID

NCT01663337

Run by

University of Washington

People needed

235

Starts

2013-03-01

Expected to finish

2019-01-01

Last updated by the study team

2018-07-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Men and women age ≥ 18 years with a current DSM-V diagnosis of alcohol abuse/dependence
• Recent alcohol consumption for at least 2 weeks in the past 30 day period OR at least 2 days of heavy drinking in the past 30 day period
• Desire to abstain from alcohol
• Current DSM-V (Diagnostic and Statistical Manual of Mental Disorders) diagnosis of PTSD
• Capacity to provide informed consent
• English fluency

You may not qualify if…

• Men and women with an unstable psychiatric medication regimen
• Current trauma-focused mental health treatment (MH) or behaviorally focused alcohol dependence (AD) AD/MH treatment in the past 30 days
• Suicide attempt or suicidal ideation with intent or plan, or self-harm in the past month
• Presence of a psychotic disorder or uncontrolled Bipolar Disorder
• Signs or symptoms of alcohol withdrawal at the time of initial consent

Where it is running

• Harborview Center for Sexual Assault and Traumatic Stress — Seattle, Washington, United States
• VA Puget Sound Health Care (Seattle Campus) — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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