Chest Imaging, Breath, and Biomarkers in a Screening Trial

Completed

Conditions studied: Lung Cancer

In brief

The investigators would like to see if lung cancer screening with chest x-rays,computer aided detection (CAD)and a lose dose CT scan can detect lung cancer in early stages when it is more responsive to treatment. The investigators would also like to see if early detection will reduce the incidence of symptomatic advanced lung cancer compared to no screening in former and current smokers with or without a family history of lung cancer who are 40-75 years old.

Key facts

Study ID

NCT01663155

Run by

The Cleveland Clinic

People needed

1424

Starts

2008-09-01

Expected to finish

2014-05-01

Last updated by the study team

2017-05-18

Who can join

Age: 40 and older, up to 75. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• ages 40-75 years
• If ages 40-59, then one of the following criteria needs to be met:
• Current or ex-smoker with >25 pack years and a family history of lung cancer(parent or sibling) OR
• current or ex-smoker with > 25 pack years and COPD OR
• current or ex-smoker with a > 35 pack year history
• If ages 60-75, then one of the following additional criteria needs to be met:
• Current or ex-smoker with >25 pack years and a family history of lung cancer (parent or sibling) OR
• Current or ex-smoker with >25 pack years and COPD OR
• Current or ex-smoker with a >30 pack year history
• Subject is able to return to Cleveland Clinic for annual follow-up screening
• Subject is willing to sign a medical release form

You may not qualify if…

• Current health requires oxygen
• Have had a chest x-ray or CT of the chest within the last 6 months
• Previous pneumonectomy
• Lobectomy of the lung within the last 5 years
• Diagnosed malignancy within the last 5 years, excluding non-melanoma skin cancer, carcinoma in situ of the cervix and localized prostate cancer
• A medical condition that would prevent treatment for lung cancer
• Within the last 6 weeks, one of the following has occured:
• A new cough or chronic cough that has gotten worse
• Either new shortness of breath, or any worsening of shortness of breath
• A cough producing blood
• Constant chest pain
• Respiratory infection, pneumonia, or cold
• Unintentional and unexplained weight loss greater than 5% of total body weight

Where it is running

• Cleveland Clinic — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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