Probiotics (L. Gasseri, B. Bifidum, B. Longum) on Immune and Intestinal Health in Healthy Older Adults
Completed · Not applicable · Has a placebo group
Conditions studied: Healthy
In brief
The purpose of this study is to determine whether healthy older adults, aged 65 to 80 years, consuming a probiotic each day for three weeks will have improved immune strength and digestive health. It is hypothesized that older adults consuming the probiotics will see a shift in their microbiota towards the "healthy" bacteria resulting in a greater proportion of immune cells, decreased inflammation, and better digestive health.
Key facts
- Study ID
- NCT01662206
- Run by
- University of Florida
- People needed
- 46
- Starts
- 2012-07-01
- Expected to finish
- 2012-12-01
- Last updated by the study team
- 2013-04-17
Who can join
Age: 65 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- 65 to 80 years of age.
- willing and able to complete the Informed Consent Form in English
- willing to provide demographic information (age, race)
- willing and able to complete daily and weekly questionnaires regarding general wellness, bowel function and gastrointestinal symptoms.
- willing to provide 4 blood, 4 stool, and 4 saliva samples
- willing to discontinue any immune-enhancing dietary supplements ( e.g., prebiotics supplements, Echinacea, fish oil, vitamin E >200% of the RDA).
- able to take the study probiotic without the aid of another person.
You may not qualify if…
- not meet the above criteria.
- taking any medication for constipation or diarrhea.
- currently taking any anti-inflammatory drugs on a regular basis.
- current smoker.
- typically consume fermented foods or probiotics (e.g., yogurts with live, active cultures or supplements).
- currently being treated for or have any of the following physician- diagnosed diseases or conditions: HIV/AIDS, immune modulating diseases (autoimmune, hepatitis, cancer, etc.), kidney disease, diabetes or gastrointestinal disease or conditions (such as ulcerative colitis, Crohn's disease, gastroparesis, cancer, peptic ulcer disease, Celiac disease, short bowel disease, ileostomy, colostomy) other than GERD or diverticular disease or have a central venous catheter.
- received chemotherapy or other immune suppressing therapy within the last year.
- received antibiotic therapy in the past two months.
- cannot schedule planned immunizations to at least 4 weeks before the start of the study, in the week following the second blood draw, or after the 4th blood draw.
Where it is running
- University of Florida — Gainesville, Florida, United States
Full record on ClinicalTrials.gov
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